BACKGROUND: Serotonin transporter promoter genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood. METHOD: Thirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene. (...) RESULTS: Children who were homozygous for the short allele of the 5-HTTLPR gene showed greater negative schematic processing following a negative mood prime than those with other genotypes. 5-HTTLPR genotype was not significantly associated with positive schematic processing. LIMITATIONS: The sample size for this study was small. We did not analyze more recently reported variants of the 5-HTTLPR long alleles. CONCLUSIONS: 5-HTTLPR genotype is associated with negative information processing styles following a negative mood prime in a non-clinical sample of young children. Such cognitive styles are thought to be activated in response to stressful life events, leading to depressive symptoms; thus, cognitive styles may index the "stress-sensitivity" conferred by this genotype. (shrink)

Just Ecological Integrity presents a collection of revised and expanded essays originating from the international conference "Connecting Environmental Ethics, Ecological Integrity, and Health in the New Millennium" held in San Jose, Costa Rica in June 2000. It is a cooperative venture of the Global Ecological Integrity Project and the Earth Charter Initiative.

OBJECTIVES: Early-emerging, temperamental differences in fear-related traits may be a heritable vulnerability factor for anxiety disorders. Previous research indicates that the serotonin transporter promoter region polymorphism is a candidate gene for such traits. METHODS: Associations between 5-HTTLPR genotype and indices of fearful child temperament, derived from maternal report and standardized laboratory observations, were examined in a community sample of 95 preschool-aged children. RESULTS: Children with one or more long alleles of the 5-HTTLPR gene were rated as significantly more nervous during (...) standardized laboratory tasks than children who were homozygous for the short alleles. Children homozygous for the short alleles were also rated as significantly shyer, by maternal report, than those with at least one copy of the long allele of the 5-HTTLPR gene. CONCLUSIONS: This study extends the literature linking the short alleles of the serotonin transporter promoter region polymorphism to fear and anxiety-related traits in early childhood and adulthood, and is one of very few studies to examine the molecular genetics of preschoolers' temperament using multiple measures of traits in a normative sample. (shrink)

Traduçáo: Normal 0 21 false false false MicrosoftInternetExplorer4 Retirado de Carlos E. Caorsi (Ed.). Ensayos sobre Strawson . Universidad de la República/Faculdad de Humanidades y Ciencias de la Educación, Montevidéo,1992, p. 55-71.

In my recent paper, “The Epistemology of Meat-Eating,” I advanced an epistemological theory that explains why so many people continue to eat animals, even after they encounter anti-factory farming arguments. I began by noting that because meat-eating is seriously immoral, meat-eaters must either (1) believe that eating animals isn’t seriously immoral, or (2) believe that meat eating is seriously immoral (and thus they must be seriously immoral). I argued that standard meat-eaters don’t believe that eating animals is seriously immoral because (...) either they don’t believe that meat-eating causes serious and systematic harm to farmed animals, or they believe that meat-eating causes serious and systematic harm to farmed animals, but they don’t believe that this harm is unnecessary. In a response titled “Are Meat-Eaters Epistemically Unlucky?”, Bob Fischer presents five objections to my epistemic theory. In this paper, I offer responses to each of Fischer’s thought-provoking objections and develop his insightful suggestion that, according to my epistemic theory, animal protectionists are victims of epistemic injustice. (shrink)

By establishing the sciences of life while, at the same time, forming a certain self-knowledge, the human being altered itself as a living being by taking on the character of a rational subject acquiring the power to act on itself, changing its living conditions and its own life …. [There is a] kinship between the discourse on limit-experience, when it was a matter of the subject transforming itself, and the discourse on the transformation of the subject itself through the construction (...) of a knowledge. (Foucault, 2000, 296)1. (shrink)